Influence of the dissolution medium on the release of dehydroepiandrosterone from lipophilic suppositories

Dehydroepiandrosterone (DHEA) is a sex steroid precursor secreted by the adrenals in humans and other primates. It converts intracellularly to bioactive androgens and estrogens [20]. DHEA and its sulfate metabolite (DHEAS) production decreases with advancing age [21]. DHEA and DHEAS play an important role in regulating body fat and the immune system. They also influence the circulation of lipoproteins and insulin sensitivity [7,8,23]. Therefore, they may protect against diseases of aging such as atherosclerosis, osteoporosis, decreased libidinal interest and diabetes [5, 6]. There is much interest in the possible benefits of administering orally DHEA to postmenopausal women and for the purposes of maintaining sexual function, youthfulness, well-being and cognition [5,27]. The effect of intravaginal DHEA on the symptoms and signs of vaginal atrophy was also studied [27]. Symptoms such as vaginal dryness, itching, burning, irritation, and dyspareunia often occur as a result of a lack of estrogens [9,22]. Endometrial hyperplasia is the side effect observed in women receiving traditional estrogen replacement therapy that also increases the risk of carcinoma [3]. Influence of the dissolution medium on the release of dehydroepiandrosterone from lipophilic suppositories